Abstract
Benzyl alcohol (BA) was used as a model compound to study subcutaneous (s.c.) drug absorption kinetics in the rat. It has been used extensively as an adjuvant in pharmaceuticals intended for parenteral administration. Benzyl alcohol has a high lipid-water partition coefficient, and is a neutral, relatively nontoxic local anesthetic. The area of s.c. tissue exposed to the BA solution was controlled by a glass absorption cell affixed to the s.c. tissue by a silicone adhesive. The about 1 percent (w/v) BA in normal saline solution was stirred in the cell at an equilibrium temperature. Multiple doses of the drug were used to monitor any volume changes in the cell. Benzyl alcohol was extracted from the fluids at the site into n-hexane and assayed spectrophotometrically at 208 mμ- The BA mean absorption half-life in the s.c. cell was 1.6hr.
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