Abstract
Bicuculline methiodide, a GABA A antagonist produced potent analgesia in the tail pinch test when it was given intracisternally (i.c.) but not intrathecally (i.t.). The ED 50 was ng/mouse. This analgesia was antagonized by i.c. muscimol, a GABA A agonist. On the contrary, muscimol (i.t.) produced bicuculline-reversible analgesia. These findings suggest that brain GABA may transmit the nociceptive information while GABA in the spinal cord may inhibit it.
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