Subconjunctival administration of "Actilize" for the treatment of small hemorrhages in the anterior chamber of the eye in cats with arterial hypertension

Abstract

Systemic arterial hypertension can occur in cats for a number of reasons. The most common causes of hypertension in cats include kidney disease (chronic kidney disease, chronic interstitial nephritis, amyloidosis, glomerulonephritis, pyelonephritis, polycystic kidney disease, renal dysplasia, as well as acute renal failure), chronic heart failure, endocrinopathy (diabetes mellitus, hyperthyroidism, etc.), obesity (hyperlipidemia), chronic anemia, polycythemia, fever, arteriovenous fistula, the use of food with a high salt content, idiopathic factors. Taking into account the above, we set a goal – to introduce into veterinary clinical practice an effective fibrinolytic "Actilize"; to establish its effectiveness in lysis of small hemorrhages in the anterior chamber of the eye with arterial hypertension of cats, as well as prevention and treatment of synechiae; to work out a subconjunctival method of administration of "Actilize" at the entrance of long ciliary arteries. The basis of the research methodology was a scientifically based formulation of the problem, methods and means of lysis of small blood clots in the anterior chamber of the eye, prevention and treatment of synechiae in cats with arterial hypertension, ensuring maximum effectiveness by improving existing treatment protocols, as well as testing "Actilize" and the subconjunctival method of its introduction in the area of the entrance of long ciliary arteries for treatment small hemorrhages in the anterior chamber of the eye with arterial hypertension of cats in veterinary ophthalmology. Thanks to the experiments, we were able to introduce into veterinary clinical practice an effective fibrinolytic "Actilize"; to establish its effectiveness in lysis of small blood clots in the anterior chamber of the eye with arterial hypertension of cats, prevention and treatment of synechiae; to work out a minimally invasive subconjunctival method of administration of "Actilize" at the entrance of long ciliary arteries. In the case of extensive hyphema with arterial hypertension of cats, followed by the formation of large blood clots, we recommended an intracameral method of introducing "Actilize" into the anterior chamber of the eye.