Abstract
Parameters of visually guided saccades were studied in 22 patients with monosymptomatic optic neuritis and 21 age-matched control subjects with a precise infrared reflection technique. Follow-up of the patients over 2.2 years, on average, allowed correlations of subclinical saccadic abnormalities, measured at study entry, with the development of clinically definite multiple sclerosis (CDMS). Subclinical adduction slowing defined on statistical grounds was observed in nine patients. Seven of these and four out of five patients with prolonged saccadic latency developed CDMS during the follow-up period. We conclude that subclinical adduction slowing in patients with optic neuritis represents an oculographic finding with pathological significance.
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