Abstract
Objective:To determine the frequency of subclinical hypothyroidism in local adult obese population.Methods:The study was conducted at Hayatabad Medical Complex, Peshawar, from March, 2017 to August, 2017. All patients aged between 18 and 60 years with BMI of more than 29kg/m2 were included in the study. Patients on lipid lowering drugs, with renal failure, hepatic failure and already diagnosed cases of thyroid dysfunction were excluded from the study. Thyroid functions were measured for all patients.Results:A total of 127 adults were included in the study in a consecutive manner. Mean age was 34.5 + 7.9 years of which 46.5% were male and 53.5% were female. Mean BMI was 32.05±2.06 kg/m2. The mean serum TSH was 3.13±1.10 mIU/L and mean serum thyroxine level was 1.08±0.25ng/dl. Subclinical hypothyroidism was recorded in 15% of the study population.Conclusion:Subclinical hypothyroidism is highly prevalent in our population with BMI of more than 29kg/m2. Further studies are recommended on relationship between thyroid functions and BMI and its effect on cardiovascular functions.
Highlights
Obesity, as defined by the BMI, is on the rise globally and in most sex-age groups is more than1
Doing a thorough literature search, we found that very little data exists about the thyroid hormone levels and its dysfunction among local adult obese population
Total of 127 adult participants having a body mass index of more than 29kg/m2 were observed to determine the frequency of subclinical hypothyroidism and results were analyzed.Age distribution among 127 patients was analyzed as; 44(34.6%) patients were
Summary
As defined by the BMI, is on the rise globally and in most sex-age groups is more than. 4. Dr Akhter Sher, FCPS, Department of Cardiology, District Headquarter Hospital, Swabi, Pakistan. The three major non-communicable diseases (NCDs) with highest mortality rate in Pakistan are cardiovascular diseases; malignancies and chronic respiratory diseases.[2] All these NCDs have few common risk factors like smoking, alcohol intake, diabetes mellitus, hypertension, dyslipidemia, obesity, unhealthy & sedentary lifestyle[3]; which can be changed resulting in prevention of these NCDs. Besides, studies have shown Asians to have a higher BMI than Europeans.[4] a lower cutoff value of BMI for overweight (23.0–24.9 kg/m2) and obese (>25.0 kg/m2) Asians has been suggested by the authorities of the international obesity task force.[4] WHO figures reveal increasing prevalence of overweight and obese adults.[5]. The present study was designed to determine the frequency of subclinical hypothyroidism in local adult obese population. This study will be an attempt to determine the frequency of subclinical hypothyroidism in local obese adult population and the results of this study will be a guideline for devising future research strategies and identifying mechanisms of preventing subclinical hypothyroidism in patients with morbid obesity
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