Abstract
Purpose: Post-transplant viral infection is a known risk factor for graft dysfunction and malignancies including PTLD. However, the impact of subclinical Epstein-Barr virus (EBV) infection on allograft injury in the renal transplant population has not yet been well defined. Method: A single center study was conducted from Oct, 2012 to Apr, 2013.We assessed EBV viremia by PCR in 327 renal transplant recipients. Results: Subclinical EBV viremia occurred in 14.7%. A multivariable linear regression analysis suggested that subclinical EBV infections are significantly associated with declines in GFR (-2.34 ± 7.00 ml/min vs. 0.98 ± 8.17 ml/min, p<0.05), log proteinuria and duration since transplantation. Conclusion: Our data demonstrated that there is an association between subclinical EBV infections and adverse outcomes in renal transplant patients, despite appropriate post-transplant antiviral prophylaxis. These findings support the need for serial viral monitoring for better outcomes in renal transplant patients.
Published Version
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