Abstract
BackgroundNon-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide. Recently, a correlation between thyroid dysfunction and NAFLD has been discussed. Objective of the present study was to investigate the association between thyroid dysfunction and hepatic steatosis.MethodsData from 2,445 subjects (51.7 % females) aged 18 to 65 years participating in a population-based cross-sectional study were assessed based on a standardized questionnaire and documentation of physical, biochemical and ultrasonographic findings. After application of exclusion criteria, a total of 1,276 subjects were included in the study collective. The influence of potential factors on the development of hepatic steatosis was assessed using multivariate logistic regression.ResultsThe prevalence of hepatic steatosis in the study collective was 27.4 % (n = 349). The serum thyroxin (TT4) concentration in subjects with hepatic steatosis was reduced (p = 0.0004). Adjusting for age, or BMI, there was an increased prevalence of hepatic steatosis in subjects with reduced TT4 concentrations (p = 0.0143; p = <.0001).ConclusionsThe findings of the present study confirm an association between both subclinical and clinical hypothyroidism and hepatic steatosis
Highlights
Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide
NAFLD subsumes a variety of entities ranging from simple fatty liver or hepatic steatosis, to non-alcoholic steatohepatitis (NASH) and cirrhosis of the liver [8,9,10] and is associated with the risk of malignant degeneration to hepatocellular carcinoma (HCC) and the increased necessity of liver transplantation [11, 12]
Hepatic steatosis The study collective included 1,276 subjects (47.2 %, females; 52.8 %, males), whose mean age stood at 40.7 ± 12.7 years (40.0 ± 12.7 years, women; 41.3 ± 12.6 years, men)
Summary
Non-alcoholic fatty liver disease (NAFLD) is one of the most common disorders of the liver worldwide. A correlation between thyroid dysfunction and NAFLD has been discussed. Non-alcoholic fatty liver disease (NAFLD) represents one of the most common chronic disorders of the liver in the Western industrialized nations [1,2,3,4]. NAFLD subsumes a variety of entities ranging from simple fatty liver or hepatic steatosis, to non-alcoholic steatohepatitis (NASH) and cirrhosis of the liver [8,9,10] and is associated with the risk of malignant degeneration to hepatocellular carcinoma (HCC) and the increased necessity of liver transplantation [11, 12].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
