Abstract
Male F344 rats were exposed to potassium bromate (KBrO3) in drinking water at concentrations of 0, 5, 20, 100, 200, or 400mg/L for 2 or 13 weeks. Endpoints evaluated included clinical observations, body weights, serum chemistry, gross pathology, organ weights, and select tissue histopathology (kidney, lung, liver, thyroid, and tunica vaginalis). Weekly body weight and water consumption means were similar between KBrO3 and control groups throughout the study. Increases in kidney weights were observed in rats of the 400mg/L group following 2- or 13-weeks exposure. Hyaline droplets were observed in renal tubules of rats of the 200 and 400mg/L groups following 2 weeks exposure and in rats of the 400mg/L group at 13 weeks. There were no KBrO3-related microscopic findings in the lung, liver, thyroid, and tunica vaginalis at the 2- and 13-week time points. A no observed effect level of 100mg/L KBrO3 (8.1mg/kg/day) was selected based on the absence of microscopic alterations in the kidney.
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