Abstract
As an alternative to MTA, a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in manyin vitroandin vivostudies. The current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies. Biochemical parameters of blood and histological parameters of the liver, kidneys, and spleen of the rats were analyzed after 120 days of consumption of the aqueous extract of ALBO-MPSA. The results showed no myelotoxic effect or autoimmune effect on peripheral blood cells and no pathological effect on the liver, kidney, and spleen tissues. Besides, no changes in the skin and hair of the rats, neither the change in the consumption of food and water, nor the change in their usual behavior were noticed during the experiment.
Highlights
As an alternative to mineral trioxide aggregate (MTA), a new endodontic material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized, and its biocompatibility has been studied in many in vitro and in vivo studies. e current study aims to evaluate a subchronic systemic toxicity of ALBO-MPSA on the rat animal model, as a continuation of the previous studies
Calcium silicate cements are bioactive materials used in various endodontic indications, such as pulp capping, pulpotomy, apexogenesis, apexification, perforation repair, and root-end filling [1,2,3,4]. e mineral trioxide aggregate (MTA) is certainly one of the most important and most widely investigated calcium silicate-based materials due to its clinical reliability and effective bone inductive potential in periapical defects after endodontic surgical treatment [5,6,7,8]
In an attempt to develop appropriate endodontic cement, a new material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized a few years ago using the nanotechnology approach [14]. e biocompatibility of ALBO-MPSA has been thoroughly studied and confirmed at in vitro and in vivo conditions and compared to MTA [14,15,16,17,18,19,20,21]
Summary
Calcium silicate cements are bioactive materials used in various endodontic indications, such as pulp capping, pulpotomy, apexogenesis, apexification, perforation repair, and root-end filling [1,2,3,4]. e mineral trioxide aggregate (MTA) is certainly one of the most important and most widely investigated calcium silicate-based materials due to its clinical reliability and effective bone inductive potential in periapical defects after endodontic surgical treatment [5,6,7,8]. E mineral trioxide aggregate (MTA) is certainly one of the most important and most widely investigated calcium silicate-based materials due to its clinical reliability and effective bone inductive potential in periapical defects after endodontic surgical treatment [5,6,7,8]. In an attempt to develop appropriate endodontic cement, a new material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized a few years ago using the nanotechnology approach [14]. E biocompatibility of ALBO-MPSA has been thoroughly studied and confirmed at in vitro and in vivo conditions and compared to MTA [14,15,16,17,18,19,20,21]. Advances in Materials Science and Engineering hypothesis was that ALBO-MPSA does not show significant experiment and every forty days to the end of the systemic toxic effects. In an attempt to develop appropriate endodontic cement, a new material based on hydroxyapatite and calcium silicates (ALBO-MPSA) has been synthesized a few years ago using the nanotechnology approach [14]. e biocompatibility of ALBO-MPSA has been thoroughly studied and confirmed at in vitro and in vivo conditions and compared to MTA [14,15,16,17,18,19,20,21].
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