Abstract
Common bean extract as a dietary supplement has received increased attention globally owing to its α-amylase inhibitory activity. The objective of this study was to evaluate the toxicity of a white kidney bean (Phaseolus vulgaris) extract by a repeated-dose 90-day subchronic oral toxicity study in Sprague-Dawley rats. In the subchronic toxicity study, 80 rats were orally administrated with white kidney bean extract at doses of 4, 2, and 1 g/kg body weight daily for 90 days. The results showed that the white kidney bean extract at doses up to 4 g/kg/day did not induce significant changes in body weight, organ weight, food consumption, hematology, serum biochemistry, and histopathology in rats, as compared to the control. The no-observed-adverse-effect level (NOAEL) of white kidney bean extract was determined to be >4 g/kg/day for both male and female rats, under the experimental conditions of this study.
Highlights
Common bean (Phaseolus vulgaris) belongs to the family Fabaceae and genus Phaseolus
Given the potential utility of α-AI-containing common beans extract as a dietary supplement, it is necessary to conduct a comprehensive toxicological assessment to demonstrate the safety of such a product for possible use in food. erefore, the objective of this study was to investigate the toxicity of a white kidney bean (P. vulgaris, WKB) extract by a 90-day subchronic oral toxicity study in rats. is study is expected to provide useful information towards the safe and effective utilization of common bean extract in food
During the 90day subchronic oral toxicity study, no apparent adverse effects or mortalities were observed in rats treated with WKB extract
Summary
Common bean is rich in starch, dietary fiber, protein, unsaturated fatty acids, and vitamin [1, 2]. It is widely consumed throughout the world, accounting for 50% of grain legumes indirect human consumption [3]. It is recognized as the major source of dietary protein in many Asian, Latin American, and African countries [4, 5]. In Tunisia, beans provided 0.50 g/capita/day proteins for Tunisian population in 2009 [7]
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