Abstract
Fischer 344 rats were fed octenyl succinate-modified food starch in a semi-purified diet from conception until they were killed 30 or 90 days after weaning. Complete autopsies and histopathological evaluations showed that growth and haematology were unaffected, but that liver, kidney and caecal weights tended to increase with increasing concentrations of dietary octenyl succinate starch. There were no consistent changes in serum chemistry values that could be associated with octenyl succinate starch intake. Female rats had higher concentrations of urinary magnesium and calcium than did male rats, and these higher mineral concentrations correlated with an increased incidence of renal cortico-medullary mineralization. The increase in mineralization of the cortico-medullary junction occurred in both control and in octenyl succinate starch-treated female rats. Pelvic nephrocalcinosis was not observed in any of the rats. It is concluded that no adverse effects associated with feeding octenyl succinate starch occurred in rats under the conditions of this study.
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