Subchronic infusion of clenbuterol, a beta-adrenergic agonist, decreases the cerebellar beta receptor

Abstract

Subchronic, peripheral infusion of clenbuterol, a β-adrenergic agonist, narkedly reduced β receptor density and isoproteronol-sensitive adenylate cyclase activity in the cerebellum of the rat. In contrast, infusion of salbutamol, isoproterenol or desipramine did not alter the β receptor. the result of clenbuterol administration demonstrates, for the first time, a significant alteration of the cerebellar β 2 receptor to a pharcologic manipulation. This alteration may influence physiological and behavioral processes regulated by the cerebellum.