Abstract
Increased subchondral cortical bone plate thickness and trabecular bone density are characteristic of knee osteoarthritis (OA). Knee joint distraction (KJD) is a joint-preserving knee OA treatment where the joint is temporarily unloaded. It has previously shown clinical improvement and cartilage regeneration, indicating reversal of OA-related changes. The purpose of this research was to explore 3D subchondral bone changes after KJD treatment using CT imaging. Twenty patients were treated with KJD and included to undergo knee CT imaging before, one, and two years after treatment. Tibia and femur segmentation and registration to canonical surfaces were performed semi-automatically. Cortical bone thickness and trabecular bone density were determined using an automated algorithm. Statistical parametric mapping (SPM) with two-tailed F-tests was used to analyze whole-joint changes. Data was available of 16 patients. Subchondral cortical bone plate thickness and trabecular bone density were higher in the weight-bearing region of the most affected compartment (MAC; mostly medial). Especially the MAC showed a decrease in thickness and density in the first year after treatment, which was sustained towards the second year. KJD treatment results in bone changes that include thinning of the subchondral cortical bone plate and decrease of subchondral trabecular bone density in the first two years after treatment, potentially indicating a partial normalization of subchondral bone.
Highlights
Knee osteoarthritis (OA) is characterized by cartilage degeneration, but by significant bone remodeling as well[1]
In one randomized controlled trials (RCTs), relatively young (
Cortical bone thickness changes one and two years after treatment with knee joint distraction, and two years compared to one year post-treatment, for patients with predominantly medial compartmental osteoarthritis (n 1⁄4 14)
Summary
Knee osteoarthritis (OA) is characterized by cartilage degeneration, but by significant bone remodeling as well[1]. In endstage knee OA, bony changes include subchondral (cortical) bone a The first two authors contributed (joint first author). Radiographs, showing a decrease in overall subchondral bone density one year after treatment with increased osteophyte formation in the first two years after treatment[9,12]. Bone changes after KJD have never been evaluated in three dimensions (3D), which enables measurement and visualization across the entire joint. The purpose of this research was to explore subchondral cortical bone plate thickness and subchondral trabecular bone density from CT imaging before and up to two years after KJD treatment
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
