Abstract
KNOWLEDGE of the subcellular localization of serotonin (5-hydroxytryptamine) in neurones is important for an understanding of the precise physiological role of this amine in nervous tissue. Some of the most pertinent pharmacological and electrophysiological data on the neuronal role of serotonin have been obtained from work with molluscs1,2. In particular there is strong evidence that the amine acts as a transmitter on one particular type of neurone in the gastropod brain2. Fractionation studies with homogenates of bivalve ganglia, which are extremely rich in serotonin, have shown that the amine is bound to particles, but associated with particles of different density from those binding acetylcholine3. The precise type of particle or particles associated with serotonin, however, is not definitely known4.
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