Abstract
While estrogen receptors have been known to represent estrogen-dependent transcription factors as part of the nuclear receptor family, a putative membrane-bound form of estrogen receptors has been suggested. Since estrogen receptor β (ERβ) is reportedly abundant in the hippocampus and other regions of the central nervous system, subcellular localization of ERβ in mouse hippocampus was investigated. ERβ was predominantly found in nuclear, synaptosomal and synaptic membrane fractions, particularly this last fraction. Immunocytochemical investigation using the NG108-15 neuroblastoma-glioma hybridoma cell line indicated that ERβ is predominantly localized in cell membranes and nuclei. These results suggest that ERβ localizes on synaptic membranes and may represent an important regulator of intracellular signal transduction from membrane to cytosol in hippocampal neurons.
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