Abstract
Studies using subcellular fractions of rat liver have revealed that α-ketoadipate dehydrogenase is principally localized in the mitochondrial fraction and that α-ketoadipate reductase is principally localized in the cell supernatant fraction. Both enzymes have the highest activity in heart muscle. The ratio of the dehydrogenase activity to the reductase activity is highest in kidney followed by heart, brain, liver, leg muscle, and small intestine. This pattern is consistent with the relative mitochondrial density of the various tissues tested, and suggests that the reductase has a dominant role in α-ketoadipate metabolism in tissues that have a low mitochondrial density.
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