Abstract
Abstract Platelets incubated in plasma containing 5 times 10−5 and 3 times 10−4 M chlorpromazine, desmonomethylchlorpromazine or chlorpromazine sulphoxide were homogenized and fractioned by differential centrifugation. After fractionation most of the accumulated chlorpromazine and desmonomethylchlorpromazine were found in the particulate fractions, while most of the chlorpromazine sulphoxide was in the supernatant. The phenothiazines studied had a certain affinity for that fraction containing most of the platelet 5-hydroxytryptamine (5-HT). These phenothiazines released half of the platelet 5-HT without altering its intracellular distribution. The distribution of 5-HT was affected only by concentrations of chlorpromazine and desmonomethylchlorpromazine which released nearly all of the platelet 5-HT.
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