Abstract
The subcellular distributions of the Auger-emitting radiopharmaceuticals 67Ga citrate, 111In-bleomycin, 63Zn-bleomycin, 123/125I-Conray and 123/125I-Biligram in human and animal tumours and normal tissues were studied using differential centrifugation. For 67Ga, at 19 to 54 h after injection, the observed subcellular distribution patterns were similar in all the tissues studied with 2-5% of the total tissue radioactivity being associated with the cell nuclei. For 63Zn and 111In administered as the bleomycin complex or as chloride, as well as for the X ray contrast media 135/125I-Conray and 123/125I-Biligram the fraction associated with the nuclei was only 1-2%. The studies indicate that, for the 67Ga, 111In, 63Zn complexes or compounds studied, only ~1 to 4% of the Auger emissions are likely to arise in the cell nucleus.
Published Version
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