Abstract
Changes taking place in a population of lysosomes were estimated from the results of investigation of the intracellular distribution of lysosomal marker enzymes: acid phosphatase and acid ribonuclease (RNase). Acute (pure CCl4, 0.15 ml/100 g body weight, by gastric tube) and chronic (inhalational poisoning by the scheme of Rabinovici and Wiener) toxic hepatitis are accompanied by increased specific activity of the enzymes in the heavy mitochondrial fraction, indicating changes in the sedimentation properties of the lysosomes. An increase in the “unsedimented” acid RNase activity in chronic toxic hepatitis is a sign of injury to the lysosomal membranes.
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