Abstract
Δ 9-Tetrahydrocannabinol- 3H (Δ 9-THC- 3H), administered intracisternally, is distributed almost equally among particulate fractions of rat brain homogenates with only a small proportion in the supernatant fraction. Similar distribution of Δ 9-THC- 3H is found when the drug is added directly to brain homogenates. Most of the metabolites of Δ 9-THC- 3H, however, are found in the supernatant fraction, but synaptosomes retain significantly greater amounts of polar metabolites than do other particulate fractions. After incubation with synaptosomes in vitro, exceptionally high tissue/medium ratios were found for Δ 9-THC- 3H accumulation. This accumulation was not prevented by metabolic inhibitors and was not temperature dependent. The results indicate that significant amounts of Δ 9-THC and its polar metabolites can be concentrated in synaptosomes by nature of the drug's lipophilic properties.
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