Abstract
Subcapsular cell hyperplasia in the adrenal glands of ICR mice, aged from 2 to 25 months, were investigated for incidence and morphological characteristics. The lesions were first observed in the 4-month-old mice of both sexes and increased gradually in incidence until reaching a plateau at 19 months of age when the incidence of males was 59% and of females was 91%. Females showed higher incidences than males at any ages examined. Subcapsular cells in the earliest lesion were of fusiform type (Type A cells) and formed scattered foci of small cellular aggregates just beneath the capsule. There were no morphological changes in the zona glomerulosa cells. The subcapsular cells then proliferated to expand their area vertically as well as horizontally and tended to form wedge-shaped hyperplastic foci. Large hyperplastic foci were composed of fusiform cells and polygonal cells (Type B cells) containing abundant cytoplasm. Fat staining showed lipid droplets in both Type A and B cells. Electron microscopic examination on the subcapsular cells revealed basement membranes, desmosomes and dense bodies which developed into intracytoplasmic vacuoles. Some subcapsular cells gathered together to form nests similar to the glands of zona glomerulosa.
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Schedule a callMore From: Nihon juigaku zasshi. The Japanese journal of veterinary science
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