Abstract
Background: This study aimed to evaluate the hospitalization rates for subarachnoid hemorrhage (SAH) among renal transplant patients with adult polycystic kidney disease (ADPKD) and its outcomes, when compared to non-ADPKD renal transplant patients. Methods: The 2005–2014 National Inpatient Sample databases were used to identify all hospitalized renal transplant patients. The inpatient prevalence of SAH as a discharge diagnosis between ADPKD and non-ADPKD renal transplant patients was compared. Among SAH patients, the in-hospital mortality, use of aneurysm clipping, hospital length of stay, total hospitalization cost and charges between ADPKD and non-ADPKD patients were compared, adjusting for potential confounders. Results: The inpatient prevalence of SAH in ADPKD was 3.8/1000 admissions, compared to 0.9/1000 admissions in non-ADPKD patients (p < 0.01). Of 833 renal transplant patients with a diagnosis of SAH, 30 had ADPKD. Five (17%) ADPKD renal patients with SAH died in hospitals compared to 188 (23.4%) non-ADPKD renal patients (p = 0.70). In adjusted analysis, there was no statistically significant difference in mortality, use of aneurysm clipping, hospital length of stay, or total hospitalization costs and charges between ADPKD and non-ADPKD patients with SAH. Conclusion: Renal transplant patients with ADPKD had a 4-fold higher inpatient prevalence of SAH than those without ADPKD. Further studies are needed to compare the incidence of overall admissions in ADPKD and non-ADPKD patients. When renal transplant patients developed SAH, inpatient mortality rates were high regardless of ADPKD status. The outcomes, as well as resource utilization, were comparable between the two groups.
Highlights
Subarachnoid hemorrhage (SAH) is a major clinical problem worldwide, associated with a poor prognosis, long-term morbidity, and extremely high mortality [1,2,3]
Among patients with autosomal dominant polycystic kidney disease (ADPKD), a disorder that affects the kidneys and other organs caused by mutations in PKD1 and PKD2, a wide spectrum of vascular abnormalities have been described including intracranial aneurysms, thoracic aorta and cervicocephalic artery dissections, and coronary artery aneurysms [11,12]
The adult polycystic kidney disease (ADPKD) renal transplant patients were older, had higher comorbidity burden, and were more likely to be admitted to teaching hospitals than non-ADPKD renal patients
Summary
Subarachnoid hemorrhage (SAH) is a major clinical problem worldwide, associated with a poor prognosis, long-term morbidity, and extremely high mortality [1,2,3]. Among ADPKD patients with a family history of SAH/intracranial aneurysms, the frequency is three to five times higher than the general population [12]. The inpatient prevalence of SAH as a discharge diagnosis between ADPKD and non-ADPKD renal transplant patients was compared. Among SAH patients, the in-hospital mortality, use of aneurysm clipping, hospital length of stay, total hospitalization cost and charges between ADPKD and non-ADPKD patients were compared, adjusting for potential confounders. There was no statistically significant difference in mortality, use of aneurysm clipping, hospital length of stay, or total hospitalization costs and charges between ADPKD and non-ADPKD patients with SAH. Conclusion: Renal transplant patients with ADPKD had a 4-fold higher inpatient prevalence of SAH than those without ADPKD. When renal transplant patients developed SAH, inpatient mortality rates were high regardless of ADPKD status. The outcomes, as well as resource utilization, were comparable between the two groups
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have