Abstract
Apholate administered to mature chickens at varying levels in the diet from 500 to 5000 ppm produced a significant depression in reproductive performance. Fertility was completely depressed in both cocks and hens. Among males, semen volume, sperm concentration, and sperm motility were greatly depressed. Testis weight of these birds was significantly depressed, and microscopic examination of these tissues revealed degeneration of the cellular elements of the seminiferous tubules. Hens fed apholate-treated diets ceased egg production, and the gonads became highly involuted. Marked leukopenia occurred among apholate-treated males and females. Appreciable changes were not found in erythrocyte numbers except in the case of severe poisoning. Males were more sensitive to high levels of apholate in the diet than females as indicated by the severity of signs of apholate intoxication and greater mortality.
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