Abstract
Patients with diabetes mellitus are more prone to infection, especially if the glycaemic control is poor. Hyperglycaemia can cause various abnormalities such as impaired polymorphonuclear chemotaxis, abnormal phagocytosis, reduced IgG or IgA levels, complement deficiency (e.g. low C4), abnormal intracellular killing and deficient cell-mediated immunity. It is also recognised that infection can predispose to diabetic ketoacidosis (DKA). Necrotising fasciitis (NF) is an unusual but life-threatening soft tissue infection. NF is a rare cause of DKA. We describe such a case and review NF with regard to both its acute and sub-acute presentations.
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