Abstract

AbstractWe report a patient with anti‐glutamate receptor (GluN2B, GluN1 and GluD2) antibody‐positive and anti‐N‐methyl‐d‐aspartate receptor antibody‐negative encephalitis presenting as cerebellar ataxia and generalized cognitive impairment. Intravenous corticosteroid pulse therapy markedly resolved his symptoms 6 weeks after onset. Marked impairment of the cortical function with a relatively preserved level of consciousness, and a favorable response to corticosteroid therapy might occur in immune‐mediated lobar encephalitis associated with anti‐glutamate receptor antibodies.

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