Subacute and Chronic Toxicities of Ascorbyl Palmitates

Abstract

SummaryWhen l-ascorbyl palmitate and d-isoascorbyl palmitate were fed subacutely for 9 months in concentrations of 2% and 5% of the diet, only the 5% levels were toxic. The growth rates of rats on the 5% levels were significantly retarded and bladder stones were produced in 2 animals on the 5% 1-ascorbyl palmitate. d-Isoascorbie acid in a concentration of 1% of the diet had no deleterious effect. Chronic toxicity studies for 2 years indicate that 1-ascorbyl and d-isoascorbyl palmitate are not toxic in concentrations of 0.25% (2500 p.p.m.), or less, of the total diet of rats. Heat-treating fresh lard containing the palmitates before adding it to the diet had no effect on toxicity.