Abstract
BackgroundFacile synthesis and small size theranostic agents have shown great potential for cancer diagnosis and treatment.PurposeA ternary compound (Cu5FeS4), Fe doped copper sulfide, with novel magnetic properties and strong near-infrared absorption was prepared for magnetic resonance imaging (MRI) imaging guided photothermal therapy of cancer.Patients and methodsFirstly, the capability of magnetic resonance imaging based on the novel magnetic properties and the photothermal performance due to the strong near-infrared absorption was investigated in vitro. Then, the magnetic resonance imaging guided photothermal therapy for 4T1 tumor-bearing mouse was carried out.ResultsThe Cu5FeS4 cube with good T1-weighted MRI, excellent photothermal performance and low cytotoxicity has been investigated. More importantly, the T1-weighted MRI for 4T1 tumor-bearing mouse will get the best contrast effect at tumor site after 8 h of intravenous injection of Cu5FeS4 cube. Under the guidance of the T1-weighted MRI, the PTT was carried out at 8 h after intravenous injection of Cu5FeS4 cube and only the group combined intravenous administration of Cu5FeS4 cube and laser irradiation nearly cured the tumor after 14 days.ConclusionOur study not only provides a new material for personalized treatment of tumors, but also further promotes potential applications of the cancer theranostic agents.
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