Abstract
Arsenic is a ubiquitous toxicant, having a wide range of toxic effects on different systems in the body. To investigate the sub‐chronic effects of exposure to low doses of cacodylic acid (organic arsenic) on some enzymes of energy metabolism and antioxidant system in the liver, rats were exposed to cacodylic acid (20 ppm and 40 ppm) in their drinking water for ten weeks. Control animals received distilled water. Activities of catalase (CAT), glutathione peroxidase (GPx), glutathione‐S‐transferase (GST), superoxide dismutase (SOD), NAD glycohydrolase (NADase), xanthine oxidase (XO) and lactate dehydrogenase (LDH) and the levels of nitric oxide (NO), reduced glutathione (GSH) and lipid peroxidation (MDA) were determined in hepatic cytosol while malate dehydrogenase (MDH) and respiratory chain enzymes (complexes I, II and IV) activities were determined in the mitochondrial fraction. There were significant (p<0.05) decreases in the level of GSH and activities of NADase, MDH and complex IV in the exposed groups compared with the control. In the 20 ppm group, activity of hepatic SOD and level of NO increased by 419% and 142% respectively. A hormetic response was observed in the activity of GST. The activities of complexes I and II decreased as a result of exposure to cacodylic acid, these decreases were dose‐dependent. Our findings indicate that disruption of energy metabolism and antioxidant system by cacodylic acid might play a role in the pathogenesis of its hepatotoxicity.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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