Sub-acute oral toxicity and in vivo antioxidant properties of Oxalis cernua

Abstract

Oxalis cernua is a medicinal herb, used as food and in folk therapy. It was introduced into the Mediterranean basin from the Cape Region (South Africa). The stems and leaves have the function of clearing heart, removing toxicity, analgesia, anti-inflammatory, neuroprotective and antihypertensive effects. The aim of the present study is to assess the sub-acute toxicity and in vivo antioxidant properties of Oxalis cernua areal part methanolic extract (OCE). Daily administration of OCE could result in alteration of liver histology and induced gastritis. In addition, OCE exhibited, in vivo, a strong effect on DPPH free radical, GSH level, and lipid peroxidation inhibition in both liver and kidneys. These findings confirmed that precautions should be taken when Oxalis cernua is given over longer periods. Furthermore, their potential antioxidant activity and the ability to prevent lipid peroxidation may have biopharmaceutical and food applications.