Su1989 Generation of Functional Human Intestinal Organoids From Lymphoblastoid B-Cell Lines: Opportunity for Gene Specific Functional Assessment in IBD

Abstract

G A A b st ra ct s in colonoid culture and we posit that activation of the TRIF signaling pathway is the main mediator of these changes. Understanding how innate immune recognition pathways crosstalk with epithelial stem cell self-renewal and differentiation pathways will be important for future studies examining the role of stem cells in homeostasis and tumor promotion. We would like to acknowledge the technical help and provision of reagents by Richard J. von Furstenberg and Susan J. Henning.