Abstract
significant difference in SerP1303 NR2B expression was observed between animals receiving short-term repetitive acid exposure/rechallenge and animals with an acute acid exposure. Similarly, no significant difference was observed in PSD-95 expression between animals receiving short-term repetitive acid exposure/rechallenge and animals with an acute acid exposure. CONCLUSIONS: In adult rats, repetitive esophageal acid exposure does not exhibit long-term molecular changes in ACC. This finding is in contrast to the previously observed effect of early-life (P7-P14) acid exposure that resulted in long-term molecular alteration in cortical neurons. The present data reinforces the fact that the neonatal acid exposure is vulnerable for altered neuronal functions in cingulate cortex and such alteration may not happen in adult.
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