Abstract
acid-induced hyperemia, further declined by IND pretreatment (10 mg/kg, sc). These results suggest that although GPR43 activation enhances duodenal mucosal defenses by increased DBS via 5HT4 activation, GPR43 activation combined with COX inhibition may increase vulnerability of duodenal mucosa to gastric acid via 5HT3 activation and reduction of blood flow. Excess 5-HT release via GPR43 activation with accompanying acid exposure may be implicated in functional dyspepsia symptoms.
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