Abstract
AFTPH overexpression reduced permeability (p<0.05). Conclusions: Our results indicate that gene silencing of AFTPH in human colonocytes increased epithelial permeability, possibly by regulating expression and localization of genes related to epithelial cell adhesion signaling. These are the first results suggesting that AFTPH may be a new gene regulating intestinal epithelial permeability. Acknowledgement: UCLA Vector Core and UCLA Clinical Microarray Core. Supported by NIH grant DK60729 (CP), P50 DK64539 (Project 2, CP), and the Blinder Research Foundation for Crohn's Disease (IKML).
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