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Abstract
as well as a reduced expression of CD80/CD86. Co-cultivation of allogenic T cells with H. pylori challenged MoDC results in an Interferon-γ secretion by T cells. However, the T cell response was modified when TLR-2 was neutralized. Conclusion: For the recognition of H. pylori by MoDC, TLR-2 plays an important role. When neutralized, MoDC induce stronger H. pylori specific T cell responses, although co-stimulatory activation markers on MoDC and secreted cytokines were reduced. The role of TLR subtypes therefore appears to have an important impact on regulation of T cell activation, andmechanisms are being investigated. Similar mechanism may account for other autoimmune diseases, which is of considerable clinical impact.
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