Su1620 Mast Cells in the Gastric Antrum, Its Relation With Functional Dyspepsia. a Multicenter Study in a South-American Country

Abstract

INTRODUCTION:Mast cells might be involved in the pathogenesis of FD, but is still unclear how to evaluate their presence in the gastric mucosa,and their association with FD and H. pylori infection. AIM: to assess the presence of an increased number of mast cells in gastric mucosa (antrum) of patients with FD subtype postprandial distress, based on Rome III criteria, with and without HP infection. MATERIAL AND METHODS: an observational multicenter study, 53 patients were enrolled consecutively, 20(38%) male, mean age 52 years, who underwent an upper endoscopy to be compared with control group (n=56). For mast cells count, biopsy samples were taken from the antrum and they were detected by Giemsa stain, and HP status was defined as a positive urease test or histologic finding.Two blinded independent pathologists assessed the mast cells number, an a third one was called when in disagreement or when the difference of mast cells number was≥4.Statistical analysis: X2test was used to compare proportions, and the Mann-Whitney test to compare numerical variables in both groups.Odds ratios (OR)were calculated using logistic regression with a significance level of 0.05 in all cases. RESULTS:see Table I and II Forward Stepwise Multiple Logistic Regression was used to identify better predictors of mast cells> 6 among the following variables: age<45,sex male, H. pylori status and dyspepsia symptoms.This model included the age(OR=8,55; p=0,005) and dyspepsia(OR=7,19; p=0,013) CONCLUSION: an increased number of mast cells in the gastric antrum ,seems to be more related to age, to functional dyspepsia symptoms than to H. pylori infection.However furher studies are necessary to confirm these findings including a higher number of cases 1FD:Functional dyspepsia 2.HP: Helicobacter pylori Results: Case group vs Control Group