Su1612 Dynamics of Aquaporin-4 in Gastric Parietal Cells in the Hyperplastic Gastric Fundic Mucosa of Histamine Type 2 Receptor Knockout Mice

Abstract

G A A b st ra ct s subjects and on the same day (n=5). Second, we evaluated the reproducibility under a different set of conditions using the same examiner, the same subjects, but on different days (n=5). Finally, we evaluated pH profile in the upper GI tract and the differences between patients taking proton pump inhibitor (PPI) and those taking H2 blocker. Results: Satisfactory data could be obtained from all patients without any complications. First, the reproducibility coefficient of each pH value by this method was 0.91 [95%CI (CI): 0.89-0.99, P < 0.01] (different examiner, same subjects and same day, n=5) and 0.83 (95%CI: 0.59-0.98, P < 0.01) (same examiner, same subjects and different days, n=5). Based on the above study results, we concluded that this method has high reproducibility. As to the intra-luminal pH profile, pH in duodenum was strictly controlled more compared to other sites. The pH profile in the stomach of patients taking PPI was significantly higher than those taking H2 blocker in patients with no endoscopic gastric mucosal atrophy (Fig.1), while there were no significantly differences in moderate to severe endoscopic gastric mucosal atrophy (Fig. 2). Conclusions: We have established a new method for assessing intra-luminal pH at 8 sites from esophagus to duodenum at one time in daily practice.