Su1589 Comparison Between Continuous Infusion and Intermittent Bolus Injection of Propofol for Deep Sedation During Endoscopic Retrograde Cholangiopancreatography

Abstract

negative predictive value of 97% for the diagnosis of malignant biliary strictures. Aim: The objective of this study was to evaluate the role of probe-based confocal laser endomicroscopy in the real-life diagnosis of biliary strictures at the time of endoscopy. Methods: A retrospective review of all patients who underwent ERCP with pCLE of biliary strictures was performed between the years 2010 and 2014 at Mount Sinai Beth Israel Medical Center. The accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were determined for brush cytology, forceps biopsy and pCLE. Results: To date, 36 patients have been identified who underwent ERCP with pCLE, brush cytology and biopsy for the workup of a biliary stricture where the final pathology was known. The diagnoses determined via pCLE, cytology, and biopsy were compared to the final diagnoses. The results of the accuracy, sensitivity, specificity, positive predictive value and negative predictive value are demonstrated in Table 1 below. Among the cases in this study, 53% were malignant and 47% were benign. Conclusion: pCLE can greatly aid in the accurate diagnosis of biliary strictures and thus can lead to improved management of patients when compared to the other diagnostic modalities. Thus pCLE may become the gold standard in the diagnosis of biliary malignancy.