Su1484 Upper Gastrointestinal Bleeding in Patients With Cirrhosis and Hepatocellular Carcinoma is Associated With Rebleeding and Increased Mortality

Abstract

Background and aims: The presence of fibrosis on liver biopsy is a prognostic tool for management of liver disease. AST/PLT ratio index (APRI) has been shown to be a useful tool to non-invasively predict fibrosis. Hepatoportal pressure gradient (HPPG) measurements have been used as an instrument to predict complications from cirrhosis. To the best of our knowledge, there has been no prior study comparing HPPG measurements to APRI scores. We aimed to elucidate the relationship between APRI scores and HPPG measurements. Methods: We retrospectively reviewed liver biopsy results of patients (n = 125) between 2009 and 2011. Patients who had no coinciding liver function tests within one week of liver biopsy (n=25) and those without coinciding measurements of hepatic venous pressures (n =58) were also excluded. A total of 67 patients were analyzed. The AST platelet ratio (APRI) were obtained and compared to HPPG =10 (n=13) mmHg. Results: Median age was 60 (range 30-80) and 38 (59%) were male. Hepatitis C was present in 35 (52%) of patients, 13 of whom had undergone liver transplantation with recurrence of hepatitis C. Table 1 shows the etiology of liver diagnoses. Mean APRI score was 0.52 + 0.51 in patients who had HPPG =10, p =0.04. Pearson's correlation between APRI score and HPPG measurement was 0.27, p = 0.03. Conclusions: AST/platelet ratio index (APRI) has been shown to be an important noninvasive diagnostic marker for fibrosis. There is a significant relationship between APRI scores and the severity of hepatoportal pressures. Etiology of liver disease diagnoses in our patients