Abstract
Endoscopic surveillance in Barrett's esophagus (BE) has major limitations including sampling error due to inconspicuous dysplasia, need for multiple biopsies and subjectivity of pathological assessment of dysplasia. Probe-based confocal laser endomicroscopy (pCLE) allows real time assessment of histological features of the esophageal epithelium. However, in patients without visible lesions, pCLE applied randomly is, like biopsies, subject to sampling error. We combined pCLE with endoscopic trimodal imaging and in vivo histology was assessed on locations targeted using autofluorescence imaging (AFI).
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