Su1433 Elective Caesarean Delivery Is Associated With Increased Celiac Disease Risk in Boys, but Not in Girls

Abstract

BACKGROUND: Celiac disease is an immune-mediated enteropathy that is secondary to gluten ingestion and is classically associated with gastrointestinal symptoms. Some studies suggest that reproductive disorders may be the first symptoms of Celiac disease in otherwise asymptomatic women. Our objective was to determine the prevalence of Celiac disease in women presenting with infertility. STUDY DESIGN: Prospective cohort study. METHODS: We collected data on demographics, screening test results, and diagnosis among women presenting with infertility from March 2012 through March 2013. Women were screened for Celiac disease using serologic testing for antibodies against tissue transglutaminase (IgAtTG). RESULTS: 1112 women presented for an initial infertility evaluation. 20 women had a previous diagnosis of Celiac disease, 20 were on a self-imposed gluten-free diet, and 839 were screened. Seven women screened positive, yielding an incidence of 0.83% among women presenting with infertility to our clinic. Median age and body mass index as well as screening results are reported in Table 1. The prevalence of Celiac disease among women presenting with infertility was 3.1% (95% CI 2.54.5). The prevalence of Celiac disease among women with unexplained infertility was 5.2% (95% CI 3.1-8.5). CONCLUSION: The prevalence of Celiac disease is approximately 3 times higher in women with infertility than the general U.S. population (0.8%); however, routine screening at the time of infertility evaluation is likely not warranted given the low incidence. Table 1. Characteristics and Laboratory Values Median (interquartile range)