Abstract
Gastric sub-epithelial lesion (SEL) can arise from within any layer of the gastric wall. A number of intramural benign and malignant non-epithelial gastric wall tumors are included in the differential diagnosis. These should be differentiated form gastric wall bulge secondary to extrinsic compression from extramural structure. Endoscopy alone cannot accurately distinguish between intramural and extramural lesions. After the introduction of endoscopic ultrasonography (EUS), locating the layer of origin and guided-tissue acquisition became possible and extramural compression became easily identified. The combination of endoscopic and sonographic morphology together with histopathological findings made the diagnosis of different lesions more accessible.
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