Abstract
Non-erosive reflux disease (NERD) accounts for more than half of cases of gastro-esophageal reflux disease. Its pathology is complex, and the disease is often not amenable to treatment with proton pump inhibitor (PPI), which are used as front-line drugs. Though surgical therapy has been reported to be effective as an alternative to drug therapy in NERD, the efficacy of endoscopic treatment in PPI-refractory NERD has not yet been studied. The aim of this study was to evaluate efficacy, safety, and long-term outcomes of endoluminal gastroplication (ELGP) in patients with PPI-resistant NERD.
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