Su1243 Risk of Colonic Neoplasia in Patients With Sporadic Duodenal Adenomas: A Multicenter Case-Control Study

Abstract

Background/Aims;In patients with gastric cancer, colorectal cancer is one of themost common synchronous cancers.Recently, preoperative colonoscopy for patients with gastric adenocarcinoma has been recommended. We aimed to assess the clinical value of colonoscopy by evaluating the frequency of colorectal neoplasm in patients with early gastric cancer(EGC) compared to healthy controls and analyzed the risk factors of advanced colorectal neoplasm in patients with EGC. Methods; The medical records of 203 patients who diagnosed as EGC and 201 healthy control matched sex and age were reviewed retrospectively. All of the subjects underwent colonoscopy for routine check-up. The frequency and clinical feature of the colorectal polyp were assessed and compared with control group. Risk factors of advanced colorectal neoplasm(high grade dysplasia, size ≥1cm, with villous component, carcinoma in situ and intramucosal cancer) in EGC were also analyzed. Results;Mean age of the patients was 61±10.3 years and 72.3% of the patients were male. The triglyceride level was significantly higher in EGC subgroup and BMI was higher in control group (P<0.05). The frequency of overall colorectal polyp was 62.6 % in the EGC group and 54.2% in the control group (p = 0.09). There was no significant difference in number of the polyps per patients between groups. However, the colorectal polyps in patients with EGC were located at right colon more frequently than in the control group(p<0.05). Advanced colorectal neoplasms were found in 10.3% of patients with EGC and 3% of controls (p <0.05). Colorectal cancers were found in 6 patients(4.6%) with EGC . By univariate analysis, patients with advanced colorectal neoplasm in EGC group were older than those with non-advanced neoplasm (66.9±12.4 vs 61.7±10.0, p=0.04). Multivariate analysis showed that the risk factors for advanced colorectal neoplasms in patients with EGC were old age and smoking. Conclusion: Although there was no significant difference in the frequency of overall colorectal polyp, the prevalence of coexisting advanced colorectal neoplasm was higher in patients with EGC than in normal population. Preoperative colonoscopy is strongly indicated in patients with EGC who are old age or smoker The present study showed that colonoscopy