Su1234 Microscopic Severity Is Related to Earlier Surgery in Newly Diagnosed CD Patients: Results From the DELTA Cohort

Abstract

Background: Adherence to therapy is a key factor when analyzing the efficacy of a given treatment in clinical practice. Inflammatory bowel disease (IBD) is associated with high rates of non-compliance to therapy. The aim of our study was to assess the prevalence of non-adherence to treatment among patients with IBD and evaluate which factors could be related. Methods: One hundred consecutive IBD outpatients (60% with Crohn’s disease and 40% with Ulcerative Colitis) filled in an anonymous questionnaire, which included information about demography, duration of the disease, specific therapy for IBD, and data possibly related to extent of non-adherence to treatment. Statistics were performed with SPSS v.18.0. For continuous variables, mean and standard deviation were calculated and for categorical variables percentages were provided. Categorical variables were compared with Fisher’s exact test. A p value <0.05 was considered statistically significant. Results: Overall non-adherence was reported by 38% (n = 38) of patients. 78.9% (n = 30) of patients reported unintentional non-adherence and 55.3% (n = 21) forgot at least one dose per week. Non-adherence was statistically associated with: high educational level (p < 0.001); the perception that medical therapy isn’t effective enough (p < 0.001); therapy with corticosteroids (p = 0.019); recent diagnosis (p = 0.020); and young age (p = 0.007). On the other hand, different factors such as gender (p = 0.668), disease type (p = 0.211), smoker status (p = 0.626), occurrence of minor side effects (p = 0.217), use of alternative medicine (p = 1.000), previous IBD-related admissions (p = 0.676) or previous surgeries (p = 0.794) did not correlate with the degree of adherence. Conclusions: The overall non-adherence is relatively high among IBD patients and gastroenterologist’s attention should be focused on it. Risk factors of non-compliance must be evaluated at each follow-up visit to improve adherence to therapy. P431 Microscopic severity is related to earlier surgery in newly diagnosed CD patients: results from the DELTA cohort V. Nuij1 *, C. Looman2, M. Rijk3, R. Beukers4, R. Ouwendijk5, R. Quispel6, A. van Tilburg7, T. Tang8, H. Smalbraak9, K. Bruin10, F. Lindenburg11, L. Peyrin-Biroulet12, C.J. van der Woude13. 1Erasmus Medical Center, Gastroenterology and Hepatology, Rotterdam, Netherlands, 2Erasmus Medical Center, Public Health, Rotterdam, Netherlands, 3Amphia Hospital, Gastroenterology & Hepatology, Breda, Netherlands, 4Albert Schweitzer Hospital, Gastroenterology & Hepatology, Dordrecht, Netherlands, 5Ikazia Hospital, Gastroenterology & Hepatology, Rotterdam, Netherlands, 6Reinier de Graaf Hospital, Gastroenterology and Hepatology, Delft, Netherlands, 7Sint Franciscus Gasthuis, Gastroenterology & Hepatology, Rotterdam, Netherlands, 8IJsselland Hospital, Gastroenterology & Hepatology, Capelle aan den IJssel, Netherlands, 9Lievensberg Hospital, Internal Medicine, Bergen op Zoom, Netherlands, 10Tweesteden Hospital, Gastroenterology & Hepatology, Tilburg, Netherlands, 11Franciscus Hospital, Gastroenterology and Hepatology, Roosendaal, Netherlands, 12Nancy University Hospital, Universite de Lorraine, Gastroenterology and Hepatology, Vandoeuvre-les-Nancy, France, 13Erasmus Medical Center, Department of Gastroenterology & Hepatology, Rotterdam, Netherlands