Su1231 The Clinicopathological Features of Intraductal Papillary Mucinous Neoplasm of the Bile Duct: Compared With Intraductal Papillary Mucinous Neoplasm of the Pancreas

Abstract

[Background/Aim] In spite of intraductal papillary mucinous neoplasm of the bile duct (IPMNB) has been recently recognized, the clinicopathological features of IPMNB still remains unclear. The aim of this study is to resolve this problem by comparing IPMNB and intraductal papillary mucinous neoplasm of the pancreas (IPMNP). [Patients]Medical records of 7 patients with IPMNB, 12 patients with intraductal papillary non-mucinous neoplasm of the bile duct (IPNB) and 51 patients with IPMNP operated on between 2000 and 2010 at our department were reviewed retrospectively. [Results] As for the difference with IPMNB and IPNB, IPMNB had more immunohistochemical staining positive cases of MUC2 and longer for the illness than IPNB. There were no differences between IPMNB and IPNB about Age, gender and tumormarkers. As for the comparison between IPMNB and IPMNP, the malignant frequency, tumor-cell type and immunohistochemical positive staining of MUC2 of IPMNB was equal with main-duct type of IPMNP. [Conclusion]Our data suggested that IPMNB had similar clinicopathological characteristics compared with main-duct type of IPMNP, not branch-type of IPMNP. IPMNB have been proposed as the biliary counterpart of main-duct type of IPMNP. There are similarities and differences between IPMNB and IPNB.