Su1178 Antibiotic Activity of Finafloxacin on Helicobacter pylori Isolates Depending on pH Value Comparing With Other Fluoroquinolone in Korea

Abstract

G A A b st ra ct s histology and/or rapid urease test. The mean duration of hospitalization was 4.6 ± 0.2 days. Of the patients, 53.7% (127/232) was confirmed H. pylori infection status before discharge. Multivariate analysis showed that ulcer of healing stage and longer duration of hospitalization are independent risk factors for discharge before confirmingH. pylori infection status. Patients with one day longer hospitalization was 20.9% less likely to discharge before confirmation of H. pylori infection status (OR 0.791; 95% CI 0.662-0.946, p = 0.010). Patients with ulcer of healing stage had more risk of discharge before confirming H. pylori infection status than patients with ulcer of active stage (OR 2.150; 95% CI 1.027-4.499, p = 0.042). Among patients who discharged before confirming H. pylori infection status, 13.3% (14/105) was lost to follow-up. Among patients found to be H. pylori-positive in the outpatient department, only 58.6% (17/29) received eradication therapy. There was no significant difference in H. pylori eradication rate between patients who received eradication therapy during hospitalization and patients who did in the outpatient department (intention-to-treat: 68.8% (53/77) vs. 60% (12/20), p = 0.594; per-protocol: 82.8% (53/64) vs. 80% (12/15), p = 0.723). CONCLUSIONS: Therewas no difference inH. pylori eradication rate according to the timing of eradication therapy in patients hospitalized due to PUB. However, because significant proportions of patients who discharge before confirming H. pylori infection status lose an opportunity for eradication therapy, it is suggested to confirm H. pylori infection and start eradication therapy before discharge in patients with PUB.