Su1131 Development and Validation of a Registry-Based Case Definition of Eosinophilic Esophagitis in the Linked Health Registries in Denmark

Abstract

G A A b st ra ct s consistent with EoE. A definitive diagnosis of EoE was established upon unresponsiveness to proton pump inhibitor (PPI) therapy. A 6-week elimination diet based on food allergy testing was proposed to EoE patients. Resolution of the disease was defined by both clinical and histological (< 5 eo/HPF) remission. RESULTS: 30 consecutive patients were included (73%male, 63% familiar history of atopy, 67% seasonal rhinoconjunctivitis, 71% aeroallergen sensitization, 40% asthma and 25% documented food allergy). The most common food sensitisation were to tomato (72%), egg (62%), pea (50%), barley (48 %), potato (48%), rye (45%), shrimps (38%), wheat (38%), lentils (38%) and rice (35%). 12/30 (40%) patients achieved complete remission on PPIs, whereas 4 additional patients had no food sensitization and were treated with topical steroids. Elimination diet was rejected by 5 out of 14 EoE patients owing to its complexity. Among those who underwent diet, 3 out of 9 (33%) achieved complete remission. CONCLUSIONS: Elimination diet based on food sensitisation skin testing achieves complete remission in 33% of adult EoE patients. More accurate diagnostic tests to detect offending foods are required for dietary management in EoE.