Abstract
sigmoidoscopy and 43,677 with negative initial screening colonoscopy). Median age at initial screening exam was 57.9 (interquartile range [IQR] 53.1, 64.1). Women comprised 51.8% of the study cohort with 42.1% White, 24.2% Hispanic, 10.7% Black, and 9.7% Asian patients. Median duration of follow-up was 46.0 (IQR 22.7, 68.2) months with a total of 557,255 person-years of follow-up. A total of 246 colon cancers were detected during the study period. Median time to cancer diagnosis was 42.9 (24.2, 61.9) months. The adjusted hazard ratio of post-screening colorectal cancer among patients with negative colonoscopy vs. negative sigmoidoscopy was 0.4 (0.3, 0.6). Results of the adjusted Cox proportional hazards regression model are presented in Table 1. Conclusions: Among average-risk patients undergoing their initial screening exam, a negative screening colonoscopy was associated with significantly reduced risk of subsequent colon cancer compared to negative sigmoidoscopy. Adjusted Multivariable Cox Regression Analysis
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