Su1030 Genetic Variation in Vitamin D Pathway DHCR7 Gene Predicts Poor Response to Pegylated Interferon-Alfa Based Therapy in Asian Chronic Hepatitis C Genotype 1-Infected Patients

Abstract

were descriptively evaluated for observed self-reportedQOL (SF-36v2) andwork productivity and activity impairment (WPAI) assessments. Assessments were scored such that lower SF36v2 Mental Component Summary (MCS) and Physical Component Summary (PCS) scores corresponded to lower QOL while higher WPAI scores represented higher levels of impairment and work time missed. Results: Among the 71,157 NHWS total respondents, 0.9% reported an HCV diagnosis, 1.3% CHF, 2.8% MI, 5.0% COPD, 10.9% Diabetes, 14.9% Depression, and 17.3%OA. Among these 7 cohorts, the HCV cohort was the second youngest with a mean age of 54 years and had the second highest proportion of male respondents (69.8%). The HCV cohort was observed to have the second lowest average MCS scores (44.6) among the seven cohorts while having mean PCS scores (43.7) that were numerically third highest (Table 1.). Full-time employment was reported by 25.0% of the HCV group, 17.2% COPD, 28.9% Depression, 14.7% MI, 20.2% OA, 11.4% HF, and 24.4% Diabetes. Numerically, the HCV cohort had the second highest reported overall work impairment scores (29.5%) among the seven conditions and was ranked between cohorts for mean total activity impairment scores (39.8%). Conclusions: Results provide further insight into QOL and productivity as reported by a population of US survey respondents with HCV. Although one-fourth of survey respondents with HCV reported full-time employment, these same individuals reported productivity losses in the forms of absenteeism and presenteeism. Further evaluation of the impact of comorbidity burden and HCV treatment on these patient outcomes is warranted. Table 1. Cohort Mean Scores