Abstract
Purpose: To demonstrate the feasibility of high spatial resolution 1H magnetic resonance spectroscopic imaging (MRSI) of human breast cancer in a clinical setting at 3T. Method and Materials: The pulse sequence consists: outer volume pre‐saturation (OVP), independent CHESS pulses for water and lipid suppression, and standard PRESS pulse sequence with an elliptical weighted k‐space sampling scheme. Ten patient studies were performed in a 3.0 Tesla whole‐body clinical imager (Siemens Trio). A four‐channel breast coil (two for each breast) was used for both MRI and MRS. Patients lay prone with their breasts in the coil wells; when possible, gentle breast compression was applied to minimize motion. After global shimming, clinical DCE‐MRI was performed which defined the volume of interest for MRSI. Data processing consisted of line broadening, standard fast Fourier transformations, and phasing. Results: All ten studies were technically successful. The spectra were acquired with FOV = 120×120mm2; TR of 1500ms, TE of 80ms, slice thickness of 14mm, and 24×24 elliptical weighted k‐space sampling with 2 averages for total acquisition of 11.9minutes. All spectra are good in spectral quality, and Cho signals are clearly visible in the MRI‐lesion area, consistent with malignancy, while there was no detectable Cho in the control area. Interestingly, the distribution of Cho signal was nonuniform across the MRI lesion. Conclusion: To our knowledge, this is the first 2D/3D MRSI study of human breast cancer with short TE (less than 135ms) at 3T and highest spatial resolution (up to 0.25cm3) to date. In summary, we have presented a robust technique for high spatial resolution in vivo 1H MRSI of human breast cancer that uses the combined advantages of high field, short TE, multi‐voxel, and high spatial resolution itself to overcome shimming and lipid suppression difficulty, and demonstrated its potential for routine clinical examination.
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